Antiulcer activity of N-phthaloyl GABA--a new GABA mimetic agent
Bhowmick, S.; Bose, R.; Pal, M.; Pal, S.P.
Indian Journal of Experimental Biology 28(2): 190-192
1990
ISSN/ISBN: 0019-5189 PMID: 2115022 Document Number: 356893
N-phthaloyl GABA (P. GABA) inhibited gastric ulceration induced by 3 hr restraint stress at 4 degrees C (CRS) in albino rats. Antiulcer activity of P. GABA was compared with sodium valproate and cimetidine. P. GABA, sodium valproate and cimetidine showed a dose dependent reduction of gastric ulceration. Pretreatment with GABA antagonists-bicuculline methiodide (0.5 mg/kg, im) or 3 mercaptopropionic acid (2 mg/kg, im) reversed the antiulcerogenic activity of both the drugs (P. GABA and sodium valproate). GABA antagonists as such did not induce gastric ulceration in normal rats.