The role of colchicine in prevention of hepatic cirrhosis induced by carbon tetrachloride
Rhoden, E.L.; Pereira-Lima, J.; Rhoden, C.R.; Mauri, M.; Pereira-Lima, J.C.; Zettler, C.G.; Barros, E.G.
Hepato-Gastroenterology 46(26): 1111-1115
1999
ISSN/ISBN: 0172-6390 PMID: 10370676 Document Number: 2012
BACKGROUND/AIMS: The present study was undertaken to determine whether colchicine has a beneficial effect in the prevention of hepatic cirrhosis when it is given simultaneously with CCl4. METHODOLOGY: Wistar rats were employed as experimental animals and divided into 6 groups: Group I received saline solution, Group II, saline solution and mineral oil; Group III, colchicine (10mug/100g) and mineral oil; Group IV, colchicine (10mug/100g) and CCl4; Group V, colchicine (5mug/100g) and CCl4; and, Group VI received saline solution and CCl4. The effect of colchicine was evaluated by liver function tests, serum total proteins, electrolytes and histological evaluation. RESULTS: The results demonstrated higher values of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and total bilirubin in groups IV and V when compared with group VI (p<0.05). No difference between group VI and groups IV and V was observed in histological evaluation, serum total proteins and electrolytes (p<0.05). CONCLUSIONS: Colchicine, as given in this study, did not have any protective effect in the prevention of cirrhosis induced by carbon tetrachloride.
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