No genetic bottleneck in Plasmodium falciparum wild-type Pfcrt alleles reemerging in Hainan Island, China, following high-level chloroquine resistance
Chen, N.; Gao, Q.; Wang, S.; Wang, G.; Gatton, M.; Cheng, Q.
Antimicrobial Agents and ChemoTherapy 52(1): 345-347
2008
ISSN/ISBN: 0066-4804 PMID: 17954685 DOI: 10.1128/aac.00711-07Document Number: 199958
Chloroquine-resistant Plasmodium falciparum was highly prevalent in Hainan, China, in the 1970s. Twenty-five years after cessation of chloroquine therapy, the prevalence of P. falciparum wild-type Pfcrt alleles has risen to 36% (95% confidence interval, 22.1 to 52.4%). The diverse origins of wild-type alleles indicate that there was no genetic bottleneck caused by high chloroquine resistance.