Chloroquine resistance in Plasmodium falciparum and its geographical distribution in Papua New Guinea
Dulay, I.S.; Gibson, F.D.; Eyeson-Annan, M.B.; Narara, A.
Papua and New Guinea Medical Journal 30(4): 281-290
1987
ISSN/ISBN: 0031-1480 PMID: 3321751 Document Number: 302059
A study to monitor the spread, frequency and degree of chloroquine resistance in Plasmodium falciparum in Papua New Guinea was started in 1978. Macro in vitro and in vivo methods of assessing the sensitivity of the parasite to chloroquine were used. The subjects were children from 78 schools. Results of tests indicated that the prevalence of chloroquine resistance was 73% in vitro and 54% in vivo. The observed levels of resistance in vivo were 86% RI, 6% RII and 8% RIII. Chloroquine resistance was found to be widespread all over the country but was mainly at the RI level.