Metabolism of 9-deoxo-16,16-dimethyl-9-methylene prostaglandin E2 in humans
Steffenrud, S.
Drug Metabolism and Disposition the Biological Fate of Chemicals 11(3): 255-265
1983
ISSN/ISBN: 0090-9556 PMID: 6135585 Document Number: 197643
Tritium-labeled 9-deoxo-16,16-dimethyl-9-methylene prostaglandin E2 was administered by intravenous injection into humans. The initial half-life in plasma was determined to be about 3 min. About 35% of the injected radioactivity was excreted in the urine and about 55% in the feces. Twenty-three urinary metabolites were identified. The metabolites included beta-oxidized and omega-oxidized products as well as metabolites in which the 9-methylene group had been biotransformed.
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