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Antigenic structure of sperm whale myoglobin. I. Partition of specificities between antibodies reactive with peptides and native protein

Lando, G.; Berzofsky, J.A.; Reichlin, M.

Journal of Immunology 129(1): 206-211

1982

ISSN/ISBN: 0022-1767
PMID: 7086130
Document Number: 196813
Anti-sperm whale Mb cleavage of sperm whale Mb yields 3 peptides: peptide I (1-55), peptide II (56-131) and peptide III (132-153). Immunosorbent columns made with these 3 peptides were used to fractionate antibody to sperm whale Mb. These columns cumulatively bind 60-70% of the total antibody present in the 4 sera studied (the amount of antibody bound by each peptide was proportional to its size). The remaining 30-40% of antibody could only bind specifically to an immunoadsorbent column of native Mb. Not all antigenic determinants on the native Mb molecule are represented on peptide fragments.

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