Fractionation of cold-sterilized plasma. a new concept in production of non-infectious plasma proteins
Stephan, W.
Arzneimittel-Forschung 32(8): 799-801
1982
ISSN/ISBN: 0004-4172 PMID: 6890353 Document Number: 195440
The hepatitis risk of protein fractions derived from pooled human plasma is eliminated by beta-propiolactone treatment and UV irradiation. The combination of this sterilization procedure with an adsorption and elution procedure leads to coagulation factor concentrates such as fibrinogen, factor VIII and factor IX concentrate and a stabilized serum preparation for intravenous use. This technology is carried out mostly at room temperature, without alcohol and minimum pollution. It seems, especially for developing countries, an attractive alternative to the widely used alcohol fractionation.