Increased yield of F VIIi from pooled plasma vs. single-donor plasma in the production of cryoprecipitates
Rácz, Z.; Thék, M.; Jánossy, A.; Pintér, J.; Baróti, C.
Archives of Medical Research 28(2): 179-182
1997
ISSN/ISBN: 0188-4409 PMID: 9204605 Document Number: 472966
Coagulation factor VIII:C yield was studied in two types of cryoprecipitates. The first group contained products from single-donor plasma units. The other group contained cryoprecipitates which were produced from pooled plasma. The volume of plasma/bag was not different between the two groups, but both the yield and the total content of F VIII:C in cryoprecipitates were significantly different. The yield of F VIII:C was higher (+20% in relative terms) in cryoprecipitates produced from pooled plasma, resulting in higher potency of such products. The positive effect of plasma pooling on the recovery of F VIII:C might be a result of reassembly of factor VIII subunits of different individuals in the plasma pools. The findings may have a role also in large-scale production of F VIII concentrates.