Top Abstract Purchase Related
Home
>
Node
>
Subnode

Prostaglandin-generating factor of anaphylaxis. II. Characterization of activity

Steel, L.K.; Bach, D.; Kaliner, M.A.

Journal of Immunology 129(3): 1233-1238

1982

ISSN/ISBN: 0022-1767
PMID: 6180001
Document Number: 194313
Anaphylaxis of lung tissue leads to the generation of prostaglandins [PG]. A portion of the prostaglandin generation is due to a unique oligopeptide termed prostaglandin-generating factor of anaphylaxis (PGF-A), which is generated during anaphylaxis. The activity of PGF-A on human and guinea pig lung was characterized: peak PG formation occurs within 5-10 min of the addition of PGF-A, Ca but not Mg is required for PGF-A activity, and both physiologic pH and temperature are necessary for optimal activity. Human and guinea pig airway and parenchymal (lung) responses to PGF-A were similar (predominately PGF2.alpha.) but were not identical to each other (guinea pig parenchyma produces thromboxane as well). PGF-A is a novel, potent mediator generated during anaphylaxis of lung tissue that may contribute to the spectrum of tissue responses seen in allergic reactions.

Document emailed within 1 workday
Secure & encrypted payments

Sharif, N.A.; Xu, S.X.; Williams, G.W.; Crider, J.Y.; Griffin, B.W.; Davis, T.L. 1998: Pharmacology of [3H]prostaglandin E1/[3H]prostaglandin E2 and [3H]prostaglandin F2alpha binding to EP3 and FP prostaglandin receptor binding sites in bovine corpus luteum: characterization and correlation with functional data Journal of Pharmacology and Experimental Therapeutics 286(2): 1094-1102
Shi, W.; Chong, B.H.; Hogg, P.J.; Chesterman, C.N. 1993: Anticardiolipin antibodies block the inhibition by beta 2-glycoprotein i of the factor Xa generating activity of platelets Thrombosis and Haemostasis 70(2): 342-345
Patrignani, P.; Panara, M.R.; Greco, A.; Fusco, O.; Natoli, C.; Iacobelli, S.; Cipollone, F.; Ganci, A.; Créminon, C.; Maclouf, J. 1994: Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases Journal of Pharmacology and Experimental Therapeutics 271(3): 1705-1712
Bird, R.C.; Bartol, F.F.; Daron, H.; Stringfellow, D.A.; Riddell, M.G. 1988: Mitogenic activity in ovine uterine fluids: characterization of a growth factor activity which specifically stimulates myoblast proliferation Biochemical and Biophysical Research Communications 156(1): 108-115
Ihle, J.N.; Keller, J.; Oroszlan, S.; Henderson, L.E.; Copeland, T.D.; Fitch, F.; Prystowsky, M.B.; Goldwasser, E.; Schrader, J.W.; Palaszynski, E.; Dy, M.; Lebel, B. 1983: Biologic properties of homogeneous interleukin 3. I. Demonstration of WEHI-3 growth factor activity, mast cell growth factor activity, p cell-stimulating factor activity, colony-stimulating factor activity, and histamine-producing cell-stimulating factor activity Journal of Immunology 131(1): 282-287
Okamoto, M.; Nakamura, H.; Harada, N.; Shirasaka, T.; Fujii, S. 1984: Characterization of the activity of growth factor from AH-130 tumor cells Gan 75(2): 136-142
Boje, K.M.; Fung, H.L. 1990: Endothelial nitric oxide generating enzyme(s) in the bovine aorta: subcellular location and metabolic characterization Journal of Pharmacology and Experimental Therapeutics 253(1): 20-26
Jaffe, B.M.; Parker, C.W.; Philpott, G.W. 1971: Immunochemical measurement of prostaglandin or prostaglandin-like activity from normal and neoplastic cultured tissue Surgical Forum 22: 90-92
Karbon, E.W.; Enna, S.J. 1985: Characterization of the relationship between gamma-aminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain Molecular Pharmacology 27(1): 53-59
Belov, A.F. 1987: Role of reinforcement as a system-generating factor in shaping the purposeful behavior of animals Vestnik Akademii Meditsinskikh Nauk SSSR 9: 22-29
Kay, A.B.; Lee, T.H.; Nagakura, T.; Papageorgiou, N.; O'Driscoll, B.R. 1983: Neutrophil chemotactic factor of anaphylaxis Monographs in Allergy 18: 284-289
Wasserman, S.I.; Goetzl, E.J.; Austen, K.F. 1974: Preformed eosinophil chemotactic factor of anaphylaxis (ECF-A) Journal of Immunology 112(1): 351-358
Halonen, M.; Pinckard, R.N.; Meng, A.L. 1973: Characterization of IgE-induced systemic anaphylaxis in the rabbit, lack of correlation between the intravascular release of histamine and anaphylactic sensitivity Journal of Immunology 111(2): 331-340
English, D.; Schell, M.; Siakotos, A.; Gabig, T.G. 1986: Reversible activation of the neutrophil superoxide generating system by hexachlorocyclohexane: correlation with effects on a subcellular superoxide-generating fraction Journal of Immunology 137(1): 283-290
Astorquiza, M.I.; Calvo, M.; Valdés, M. 1993: Anaphylaxis inhibitory factor: clinical evaluation in pediatric patients Journal of Investigational Allergology and Clinical Immunology 3(2): 92-95
Arena, A. 2010: Anaphylaxis to apple: is fasting a risk factor for LTP-allergic patients? European Annals of Allergy and Clinical Immunology 42(4): 155-158
Fésüs, L.; Csaba, B.; Muszbek, L. 1977: Platelet activating factor, the trigger of haemostatic alterations in rat anaphylaxis Clinical and Experimental Immunology 27(3): 512-515
Thorn, R.M.S.; Greenman, J.; Austin, A. 2006: An in vitro study of antimicrobial activity and efficacy of iodine-generating hydrogel dressings Journal of Wound Care 15(7): 305-310
Geotzl, E.J.; Austen, K.F. 1977: Eosinophil chemotactic factor of anaphylaxis (ECF-A): cellular origin, structure and function Monographs in Allergy 12: 189-197
Watanabe, K.; Iguchi, Y.; Iguchi, S.; Arai, Y.; Hayaishi, O.; Roberts, L.J. 1986: Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9 alpha-11 beta,15-trihydroxyprosta-5,13-dien-1-oic acid (9 alpha,11 beta-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2 alpha by bovine lung prostaglandin F synthase Proceedings of the National Academy of Sciences of the United States of America 83(6): 1583-1587