Platelet activating factor, the trigger of haemostatic alterations in rat anaphylaxis
Fésüs, L.; Csaba, B.; Muszbek, L.
Clinical and Experimental Immunology 27(3): 512-515
1977
ISSN/ISBN: 0009-9104 PMID: 862236 Document Number: 120261
Platelet-activating factor (PAF) generated by an IgE-mediated reaction in the peritoneal cavity of rats was partially purified by adsorption to diatomaceous earth. It aggregated rat platelets and activated Hageman factor in in vitro and in in vivo conditions. The hemostatic alterations induced by PAF showed similarity to those observed in the early phase of rat anaphylaxis.
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