Diagnosis of heterozygotes in Glanzmann's thrombasthenia
Stormorken, H.; Gogstad, G.O.; Solum, N.O.; Pande, H.
Thrombosis and Haemostasis 48(2): 217-221
1982
ISSN/ISBN: 0340-6245 PMID: 6217584 Document Number: 193768
A study of a family with a propositus suffering from classical thrombasthenia type I has shown that the new immunochemical methods detect heterozygotes with high reliability. There was no overlapping between heterozygotes and normals, and the concentration of the glycoproteins IIb-IIIa-complex is remarkable constant around 50-60% in the heterozygotes. Furthermore, heterozygotes as a group show an increased bleeding tendency.