Enhancement of Naja naja atra antivenin production in horses
Liau, M.Y.; Huang, R.J.; Chen, S.W.
Zhonghua Minguo Wei Sheng Wu Ji Mian Yi Xue Za Zhi 15(4): 294-299
1982
ISSN/ISBN: 0253-2662 PMID: 7183425 Document Number: 193693
As the conventional hyperimmunization schedule in horses introduced by Tanaka could not produce enough neutralizing antibody against Naja naja atra venom, the mixture of Carboxymethyl cellulose (CMC)-Cobra venom incorporated with adjuvant was used for immunization. The neutralizing antibody produced (30 LD50) seemed to be increased but still not to reach the satisfactory level. By using CMC-Cobratoxin adjuvant mixture as an immunizing agent, highly potent antivenin (220 LD50) was obtained.