Preparation of toxoid from Taiwan cobra (Naja naja atra) venom
Miao, B.L.; Liau, M.Y.; Huang, R.J.; Chen, S.W.; Chen, T.K.; Chang, S.C.
Zhonghua Yi Xue Za Zhi 46(1): 1-6
1990
ISSN/ISBN: 0578-1337 PMID: 2176918 Document Number: 357702
Potency of sixty antitoxic unit was reached after two immunizations in 2-week intervals of rabbits and horses with 10-25 mg Taiwan cobra (Naja naja atra) venom which was detoxified by 0.125% glutaraldehyde. Now this procedure has become a routine antivenine-producing method by which snake bivalent neurotropic antivenine is produced. The stability test showed that Taiwan cobra toxoid kept at 37 degrees C for 40 days, the antigenicity increased by 24% and toxicity decreased by 10% as compared to the toxoid maintained at 4 degrees C.