Effects of naftidrofuryl on cerebral hemodynamics, metabolism and function after a retracted ischaemia
Le Poncin-Lafitte, M.; Grosdemouge, C.; Roy-Billon, C.; Duterte, D.; Rapin, J.R.
Archives Internationales de Pharmacodynamie et de Therapie 260(2): 218-229
1982
ISSN/ISBN: 0003-9780 PMID: 7165427 Document Number: 193012
Unilateral microemboli were formed in the brains of Long Evans rats by means of an intracarotid injection of microspheres (50 .mu.). This embolization resulted in a decrease in blood flow, severe cerebral edema and a modification of glucose uptake. These microemboli affected a conditioned avoidance response. Naftidrofuryl enabled a better recovery of the processes involved in the expression of acquisition. This was related to a decrease in the development of edema on 1 side and to a better glucose uptake on the other. Naftidrofuryl evidently influences the sequelae of rapidly regressive ischemia.