Effects of carnosine on systemic hemodynamics and myocardial metabolism in rats in the early postresuscitation period
Rusakov, V.V.; Dolgikh, V.T.
Biulleten' Eksperimental'noi Biologii i Meditsiny 113(4): 358-360
1992
ISSN/ISBN: 0365-9615 PMID: 1391887 Document Number: 394581
It was demonstrated in experiments on male rats that acute lethal blood loss and subsequent resuscitation after 4- and 6-min clinical death induce lipid peroxidation processes, decreased antioxidant enzyme activity, cause activation of anaerobic glycolysis in the myocardium. This metabolic heart impairment causes hemodynamic instability in postresuscitation period. 25 mg/kg of carnosine injected during resuscitation decreased functional-metabolic heart impairments and hemodynamic disarrangement as well as early postresuscitation lethality. The authors attribute positive carnosine effect to its significant antioxidant activity.