Inhibition of lysosomal enzyme liberation by indomethacin in vivo
Damas, J.; Bourdon, V.
Comptes Rendus des Seances de la Societe de Biologie et de ses Filiales 176(5): 744-749
1982
ISSN/ISBN: 0037-9026 PMID: 6220782 Document Number: 192168
The volume of the peritoneal exudate induced in the rat by iota carrageenan is reduced by subcutaneous administration of indomethacin while the concentrations of three lysosomial enzymes in the exudate are slightly increased or not modified. Thus, the total enzymatic activities of the exudate are reduced by indomethacin. The leucocyte accumulation remains unchanged in the indomethacin treated rats. During the development of the peritoneal exudate, the circulating plasma displays a high degree of lysosomial enzymes activity which is suppressed by indomethacin at the dose of 4 mg/kg.