Experimental study on immunochemotherapy using schizophyllan
Mitani, M.; Iwano, K.; Arika, T.; Kikuchi, M.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(1): 122-128
1982
ISSN/ISBN: 0385-0684 PMID: 6223586 Document Number: 192169
Immunochemotherapy with schizophyllan (SPG) combined with chemotherapeutic agents was evaluated in two syngeneic tumor-C3H/He mouse systems. The administration of SPG alone caused a significant growth inhibition of MM 46 mammary carcinoma, the highest therapeutic effect being obtained by SPG given at the advanced stage of tumors. When combined with neocarzinostatin given 7-times every other day the simultaneous administration of SPG produced an optimal response to that therapy. In X-5563 plasmacytoma, SPG alone was ineffective. However, when combined with mitomycin C given with 1 to 5-days interval, the concurrent administration of SPG prolonged significantly the life-span of the tumor-bearing mice. These results indicated that the simultaneous administration of SPG and antitumor drugs may be a useful application method for immunochemotherapy of experimental tumors.