Exacerbation detection in multiple sclerosis by clinical and evoked potential techniques: a preliminary report
Likosky, W.; Elmore, R.S.
Advances in Neurology 32: 535-540
1982
ISSN/ISBN: 0091-3952 PMID: 7054982 Document Number: 191428
The EP is well demonstrated as a useful indicator of subclinical demyelinating disease. Our study performed on patients well defined as MS and monitored closely for clinical exacerbations demonstrated an unexpectedly high occurrence of significant worsening in EP parameters. These changes occurred in the presence or absence of clinical worsening. The parameter changes may represent new demyelination or other pathologic or neurophysiologic changes in neuropathologically static lesions.