Effect, on renal function, of a product rich in polyunsaturated fatty acids: results obtained in healthy subjects
Bernardi, P.; Bastagli, L.; Pecoraro, F.; Vitolo, A.; Minelli, C.; Cavazza, M.; Adani, C.
Bollettino della Societa Italiana di Biologia Sperimentale 58(1-2): 55-59
1982
ISSN/ISBN: 0037-8771 PMID: 6802154 Document Number: 191051
In 7 healthy subjects a 2,5 mg/Kg dose of i.v. phosphatidylcholine a drug with an high content of polyunsaturated fatty acids, caused variations in renal functionality as follows: a statistically significant increase of: urine flow, renal blood flow, glomerular filtration rate and sodium excretion. The above phenomena which resulted in a hypertonic poliuria, were detected during three 30 mins clearance periods. In other 5 subjects, a dose of lysine acetylsalicylate (10,5 mg/Kg) either suppressed the phenomena induced by the previous administration of phosphatidylcholine or prevented them to appear when the drug was given successively. Authors suggest that the data obtained may be ascribed to stimulation of local PG synthesis.