Part I. Theory and computer simulation for cerebrospinal infusion
Maeda, H.; Matsukado, Y.; Iwai, Z.; Uemura, S.; Kuratsu, J.; Takeshita, J.; Sano, Y.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(6): 1040-1045
1982
ISSN/ISBN: 0385-0684 PMID: 6223592 Document Number: 189955
A pharmacokinetic one-compartment model for the cerebrospinal infusion for the brain tumor chemotherapy is described together with various parameters used for computer simulation. An antitumor protein, neocarzinostatin (NCS) as a prototype drug, has been utilized since it was found effective against glioblastoma cells at extremely low concentration (less than 5 ng/ml) and it is readily inactivated by serum. A very slow infusion velocity was found necessary for an appropriate dose regimen; for example, 0.25mg of the drug should be infused into CSF for about 40 min to attain a drug level of 8 ng/ml.