Part I. Theory and computer simulation for cerebrospinal infusion

Maeda, H.; Matsukado, Y.; Iwai, Z.; Uemura, S.; Kuratsu, J.; Takeshita, J.; Sano, Y.

Gan to Kagaku Ryoho. Cancer and ChemoTherapy 9(6): 1040-1045

1982


ISSN/ISBN: 0385-0684
PMID: 6223592
Document Number: 189955
A pharmacokinetic one-compartment model for the cerebrospinal infusion for the brain tumor chemotherapy is described together with various parameters used for computer simulation. An antitumor protein, neocarzinostatin (NCS) as a prototype drug, has been utilized since it was found effective against glioblastoma cells at extremely low concentration (less than 5 ng/ml) and it is readily inactivated by serum. A very slow infusion velocity was found necessary for an appropriate dose regimen; for example, 0.25mg of the drug should be infused into CSF for about 40 min to attain a drug level of 8 ng/ml.

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