Production of enteritis in pigs by the oral inoculation of pure cultures of Campylobacter coli
Olubunmi, P.A.; Taylor, D.J.
Veterinary Record 111(10): 197-202
1982
ISSN/ISBN: 0042-4900 PMID: 7135771 Document Number: 189920
Pure cultures of an isolate obtained from small intestinal lesions in a seven-day-old piglet were inoculated into hysterectomy-derived, colostrum-deprived piglets, conventional sucking piglets and conventional weaned pigs in three separate controlled experiments. Rectal temperatures rose to 40 deg C in inoculated hysterectomy-derived, colostrum-deprived pigs within four days of infection and a mucoid yellowish diarrhoea containing occasional flecks of blood developed. C. coli was isolated only from the faeces of the infected pigs and from all levels of their intestines at post mortem examination 12 days after inoculation. The small intestine was flaccid, pale and thickened in all cases, the contents were mucoid, the mucosa was hyperaemic and the mesenteric lymph nodes were enlarged. Mild villous atrophy and inflammatory changes were seen in the small intestines of the inoculated pigs. Mild colitis was present in both inoculated animals and controls. Agglutinating antibody was present only in serum from the inoculated pigs, at titres of up to 1:640. Similar changes were seen in conventional sucking piglets but in the weaned pigs no definite clinical signs were observed although the pathological changes were present. Both C. coli and other enteric pathogens were present in the herd of origin of the conventional pigs.