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Thermostability of inosine and its 8-substituted derivatives

Serova, I.P.; Seleznev, A.P.; Komarov, E.V.; Trofimov, V.A.

Antibiotiki 27(6): 409-413

1982

ISSN/ISBN: 0003-5637
PMID: 7114826
Document Number: 189475
The derivatographic investigation of high temperature of inosine and its 8-substituted derivatives showed that the process of destruction involved 2 stages: low temperature endothermic decomposition at 120-220 degrees C without liberation of gaseous products (stage I) and high temperature exothermic decomposition to form water (stage II). The presence of electronegative 8-substituents in the inosine molecule made easier the cleavage of the N-glycoside link. This allows the conclusion that the reaction involved formation of intermediate ionic compounds based on ribose and hypoxanthine.

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