Cytogenetic effects of pesticides. I. Induction of micronuclei in mouse bone marrow by the insecticide Dursban
Amer, S.M.; Fahmy, M.A.
Mutation Research 101(3): 247-255
1982
ISSN/ISBN: 0027-5107 PMID: 6178020 Document Number: 189023
The induction of micronuclei in mouse bone marrow by the organophosphorous insecticide Dursban was tested. Three routes of administration were used for the pure insecticide: i.p., oral and dermal. The different routes of treatment with Dursban induced a statistically significant increase in the percentage of polychromatic erythrocytes over that of the control. Both i.p. and oral treatments with the insecticide induced a high percentage of polychromatic erythrocytes with micronuclei, whereas dermal treatment did not induce micronuclei. [This study has applications to human pollution health hazard.].