Cytogenetic effects of pesticides. II. Induction of micronuclei in mouse bone marrow by the insecticide gardona
Amer, S.M.; Fahmy, M.A.
Mutation Research 117(3-4): 329-336
1983
ISSN/ISBN: 0027-5107 PMID: 6855789 Document Number: 218339
The induction of micronuclei in mouse bone marrow by the organophosphorus insecticide gardona (also known as tetrachlorvinphos) was tested. Three routes of administration were used for the pure insecticide: i.p., oral and dermal. The different routes of treatment with gardona caused toxicity of marrow indicated as significant increases in the percentage of polychromatic erythrocytes [PE] over that of the control. I.p. and oral treatments induced a statistically significant percentage of micronucleated PE.