Systemic reactions in rats following the initiation of a local inflammatory process by subcutaneous administration of spirits of turpentine
Baumgartner, R.; Obenaus, H.; Schmook, F.P.; Walzl, H.
Arzneimittel-Forschung 32(11): 1463-1467
1982
ISSN/ISBN: 0004-4172 PMID: 6891253 Document Number: 188824
Local inflammation was induced in rats by single (1 x 4 ml/kg) or multiple (14 X 0.2 ml/animal) infections of turpentine. The induction of inflammatory processes in both groups resulted in anemia and granulocytosis following an initial leukopenia. Thrombopenia on the second day, followed by thrombocytosis, was also observed in both groups. Studies on blood chemistry parameters revealed a decline in serum albumin; elevation of alkaline phosphatase in serum was observed only after multiple injection of turpentine. In these animals an elevation in the weights of spleen and adrenals and a reduction in the weight of thymus were also found.