Influence of melatonin and diclofenac on circadian rhythm of locomotor activity in rats with local inflammatory arthritis
Popov, A.V.; Naumov, S.S.; Arushanian, É B.
Eksperimental'naia i Klinicheskaia Farmakologiia 77(10): 6-9
2014
ISSN/ISBN: 0869-2092 PMID: 25518520 Document Number: 678947
Inflammatory arthritis is accompanied by disorganization of the circadian rhythm of locomotion in rats. Control saline injections increased the rhythm disturbances. Chronic administration of melatonin (5 mg/kg) attenuated these chronopathological shifts. Diclofenac demonstrated much lower positive chronopharmacological activity than did melatonin.
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