Investigating the incidence of injection-site reactions associated with administration of oxaliplatin into a peripheral vein and management local adverse reactions
Hibi, S.; Tatematsu, M.; Nishio, S.; Miyatani, M.; Tosaki, K.; Ohara, M.; Maeda, T.; Tomita, N.; Kawai, M.; Ina, K.; Oishi, K.; Muro, K.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 38(9): 1447-1452
2011
ISSN/ISBN: 0385-0684 PMID: 21918339 Document Number: 649848
In Aichi Cancer Center Hospital, we investigated the incidence of injection-site reactions associated with the administration of Oxaliplatin into a peripheral vein. We evaluated the frequency and severity of symptoms, and studied ways to manage its adverse reactions from September 2009 through March 2010. Oxaliplatin was injected into a peripheral vein in more than 90% of patients, suggesting that there would be a high risk of injection-site reactions. About 60% of patients had a numeric rating score of 5 or higher in this study, and more than 60% of injection-site reactions were improved by warming the injection site. Our results suggest that warming the injection site is one effective way to manage local adverse reactions when Oxaliplatin is administered into a peripheral vein.