Incompatibility of cefotiam dihydrochloride in parenteral preparation by high-performance liquid chromatography
Tanno, K.; Ikarashi, K.; Sasahara, K.; Kato, M.
Japanese Journal of Antibiotics 35(5): 1177-1182
1982
ISSN/ISBN: 0368-2781 PMID: 6290703 Document Number: 188799
Change in external appearance, pH values and residual antimicrobial potency of cefotiam dihydrochloride (CTM) upon combination with infusion solutions and other injections was investigated. The combinations of CTM with bromhexine hydrochloride 2 mg/ml, 2 ml, dipyridamole 5 mg/ml, 2 ml and gabexate mesilate 100 mg/vial respectively were found to be incompatible on account of turbidity produced. As for 34 other combinations, no change in their appearance, pH and potency was observed.