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Sequence homology and structural comparison between the chromosomal human alpha 1-antitrypsin and chicken ovalbumin genes

Leicht, M.; Long, G.L.; Chandra, T.; Kurachi, K.; Kidd, V.J.; Mace, M.; Davie, E.W.; Woo, S.L.

Nature 297(5868): 655-659

1982

ISSN/ISBN: 0028-0836
PMID: 6979715
Document Number: 188119
The human chromosomal alpha 1-antitrypsin gene has been cloned. This gene is approximately 5 kilobase pairs long and contains three intervening sequences in the peptide-coding region. DNA sequences coding for the amino and carboxyl termini of a alpha 1-antitrypsin have been identified. Human alpha 1-antitrypsin and chicken ovalbumin show significant sequences homology and belong to a common protein super-family. Yet the number, position and size of intervening sequences reveal that the two genes are dissimilar.

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