Effect of cyproheptadine on bar-pressing for food reward in rats
Radha Bai, S.; Rai, U.C.; Thombre, D.P.
Indian Journal of Physiology and Pharmacology 26(3): 215-220
1982
ISSN/ISBN: 0019-5499 PMID: 7174068 Document Number: 187980
Lever pressing rate under a continuous reinforcement schedule for food reward in rats was reduced significantly by cyproheptadine in the dose of 5 and 10 mg/kg body weight. Under fixed ratio schedule of reinforcement, the responding was also suppressed significantly by 5 and 10 mg/kg body weight doses of cyproheptadine. However, high dose (20 mg/kg) of cyproheptadine administered subsequent to the low doses, failed to inhibit the bar pressing rate under either continuous or fixed ratio schedules.