Anti-spasmogenic effect of cyproheptadine on guinea-pig ileum
Reylon, V.; Siddiqui, H.H.
Indian Journal of Physiology and Pharmacology 27(4): 342-344
1983
ISSN/ISBN: 0019-5499 PMID: 6678244 Document Number: 210943
Antagonistic activity of cyproheptadine against common spasmogens, like acetylcholine, histamine, serotonin, bradykinin and angiotensin, was studied on isolated guinea-pig ileum. Cyproheptadine produced a reversible antagonism of non-competitive type and was most effective against serotonin. It was less potent against histamine, bradykinin and angiotensin and least potent against acetylcholine.
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