Action of vinblastine on myenteric neurones of guinea-pig ileum
Rao, K.S.; Deshpande, S.B.; Rani, R.
Archives Internationales de Pharmacodynamie et de Therapie 258(1): 71-83
1982
ISSN/ISBN: 0003-9780 PMID: 7138146 Document Number: 185867
Motor activity of guinea pig ileum in vitro was monitored by recording isometric tension. Superfusion of the serosal surface with vinblastine (22 .mu.M) increased the motility of ileum but failed to do so in the presence of local anesthetics and also in preparations depolarized with K+-Tyrode. Atropine (6 .mu.M) or pentolinium (186 .mu.M) reduced the motor response of vinblastine but higher concentration of atropine (60 .mu.M) or pentolinium (930 .mu.M) did not further attenuate the response. Strychnine (58 .mu.M) reversibly blocked the atropine-resistant motor response elicited by vinblastine. Vinblastine produces its motor effects by stimulating the non-cholinergic and to some extent cholinergic excitatory neurons of myenteric plexuses. [Vinblastine, an alkaloid used in the chemotherapy of malignant disease had been reported to affect the absorptive and motor functions of the small intestine.].