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Relations between structure and activity in local anesthetics. I. Amino-esters and amino-éthers

Foussard-Blanpin, O.; Quevauviller, A.

Annales Pharmaceutiques Francaises 40(2): 133-142

1982

ISSN/ISBN: 0003-4509
PMID: 7137809
Document Number: 187904
Approximately 40 products (esters and ethers) were studied for their local anesthetic activity upon rabbit cornea, guinea pig back and isolated frog sciatic-gastrocnemial preparations and for their toxicity in mouse injected s.c. Different local anesthetic activities of hydroxylation, desamination or extension of intermediate chain of procaine carbamoylation of amino ester and amino ether derivatives of procaine nature of substitutive nitrogenic chain upon norpinanic and norpinenic amino ethers and butylation of different molecules were studied.

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