Stimulation of non-specific resistance and specific immune response against tumours in mice by synthetic muramyl dipeptide
Nĕmecková, S.; Bubeník, J.; Jezek, J.; Zaoral, M.
Folia Biologica 28(5): 327-333
1982
ISSN/ISBN: 0015-5500 PMID: 7173449 Document Number: 186792
Synthetic MDP administered in an aqueous medium at relatively high doses stimulated nonspecific and specific tumor immunity. Nonspecific inhibition of tumor growth was observed in B10 mice injected with 1 mg of MDP 14 days before transplantation of 3-methylcholanthrene-induced sarcoma cells. MDP in an aqueous medium increased specific tumor immunity when injected at a dose of 1 mg/mouse together with irradiated tumor cells.
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