Potentiation of the thymosin immunoregulatory effect by hypocorticoidism in rats with DMBA-induced carcinogenesis in mammary glands
Grinevich YuA; Kamenets LYa
Neoplasma 29(1): 19-27
1982
ISSN/ISBN: 0028-2685 PMID: 6803177 Document Number: 186205
Effect of adrenalectomy and or thymosin administration on the tumor growth and immunity system were investigated on the models of 7.12-dimethylbenza(a)anthracene(DMBA)-induced mammary neoplasms in rats. Adrenalectomy and thymosin administration resulted in antitumorigenic action, whereas maximal inhibiting effect was achieved after thymosin injection in adrenalectomized animals. The maximal antitumorigenic effect of thymosin in adrenalectomized rats was accompanied by synergistic immunopotentiating effect of thymosin and adrenalectomy. Immunorehabilitation with thymosin and simultaneous correction of hormone production in the adrenal cortex are believed to enhance the effectiveness of therapy in cancer patients.