Modulation of DMBA induced genotoxicity in bone marrow by quercetin during skin carcinogenesis
Sengupta, A.; Ghosh, S.; Das, S.
Journal of Experimental and Clinical Cancer Research Cr 20(1): 131-134
2001
ISSN/ISBN: 0392-9078 PMID: 11370819 Document Number: 529490
Effect of quercetin was studied on 7,12-dimethyl-benzanthracene (DMBA)-induced skin carcinogenesis in young adult Swiss albino mice. Quercetin, a naturally occurring phenolic flavonoid widely distributed in plants, was administered continuously with the diet (2%) for four weeks and chromosomal aberration, a predictor of future cancer risk, studied in the bone marrow cells at different time intervals. Significant reduction of chromosomal aberration was observed in bone marrow after four weeks (P<0.02). The reduction was first evident after 96 h, although it was not significant at this stage. Significant decrease occurred from the 21st day onward when quercetin was given in concomitance with DMBA indicating a definite protective effect of quercetin on chromosomal aberration.