Low incidence of GvHD and rejection after pharmacological ex vivo modulation of bone marrow in 2-3 antigens mismatched BMT
De Manzini, A.; Andolina, M.; Agosti, E.; Giorgi, R.; Locatelli, F.; Bonetti, L.; Miniero, R.; Busca, A.; Porta, F.; Lanfranchi, A.
Bone Marrow Transplantation 11(Suppl 1): 114-116
1993
ISSN/ISBN: 0268-3369 PMID: 8448533 Document Number: 410975
2-3 antigens mismatched BMT were performed on 32 children without a matched sibling donor. In the light of previous in vitro studies, which suggested a role of Vincristine and Methilprednisolone ex vivo treatment in modulating alloreactivity of T cells, bone marrow was treated with such a pharmacological cocktail before being infused. Acute GVHD 2 degrees to 4 degrees degree occurred in 46% of cases, chronic GVHD in 28%, graft failure in 13%. There was no significant difference between 2- and 3-antigens mismatched BMT as far as GVHD and graft failure are concerned.