Top Abstract Purchase Related
Home
>
Node
>
Subnode

In vivo detection of alloreactive T cells of host origin after rejection of HLA-identical allogeneic bone marrow transplant

Irlé, C.; Kaestli, M.; Chapuis, B.; Jeannet, M.

Schweizerische Medizinische Wochenschrift 115(43): 1525-1526

1985

ISSN/ISBN: 0036-7672
PMID: 3909389
Document Number: 244909
Rejection and graft vs host disease after HLA-identical allogeneic bone marrow transplantation are probably due to in-vivo T-cell reactivity against non-MHC antigens. Peripheral blood lymphocytes from a patient transplanted for aplastic anemia have been obtained during graft failure and tested for their alloreactivity towards unrelated and marrow donor lymphocytes. Their caryotype was determined. Our results demonstrate (1) alloreactive T cells of host origin and (2) the presence of donor-specific host cells in vivo, providing evidence for rejection following in vivo sensitization to non-MHC antigens.

Document emailed within 1 workday
Secure & encrypted payments

Lachance, S.; Le Gouvello, S.; Roudot, F.; Kuentz, M.; Bernaudin, F.; Beaujean, F.; Bierling, P.; Cordonnier, C.; Farcet, J.P.; Vernant, J.P. 1997: Predictive value of host-specific donor helper T-cell precursor frequency for acute graft-versus-host disease and relapse in HLA-identical siblings receiving allogeneic bone marrow transplantation for hematological malignancies Transplantation 64(8): 1147-1152
Vannucchi, A.M.; Bosi, A.; Grossi, A.; Guidi, S.; Saccardi, R.; Lombardini, L.; Rossi-Ferrini, P. 1992: Stimulation of erythroid engraftment by recombinant human erythropoietin in ABO-compatible, HLA-identical, allogeneic bone marrow transplant patients Leukemia 6(3): 215-219
Martin-Algarra, S.; Bishop, M.R.; Tarantolo, S.; Cowles, M.K.; Reed, E.; Anderson, J.R.; Vose, J.M.; Bierman, P.; Armitage, J.O.; Kessinger, A. 1995: Hematopoietic growth factors after HLA-identical allogeneic bone marrow transplantation in patients treated with methotrexate-containing graft-vs.-host disease prophylaxis Experimental Hematology 23(14): 1503-1508
Piatkin, E.K.; Baranov, A.E. 1977: Chromosome lesions caused by cyclophosphane in the bone marrow cells of a female aplastic anemia patient in the process of preparation for an allogeneic bone marrow transplant Problemy Gematologii i Perelivaniia Krovi 22(3): 12-16
Cooper, M.H.; Maraninchi, D.; Gastaut, J.A.; Mannoni, P.; Carcassonne, Y. 1993: HIV infection in autologous and allogeneic bone marrow transplant patients: a retrospective analysis of the Marseille bone marrow transplant population Journal of Acquired Immune Deficiency Syndromes 6(3): 277-284
Liem, L.M.; van Noort, J.T.; Goulmy, E. 1996: Anti-host cytotoxic T cells of bone marrow transplant recipients with or without graft-versus-host disease are equally sensitive to cyclosporin a Bone Marrow Transplantation 18(1): 73-78
Ringdén, O.; Remberger, M.; Persson, U.; Ljungman, P.; Aldener, A.; Andström, E.; Aschan, J.; Bolme, P.; Dahllöf, G.; Dalianis, T. 1995: Similar incidence of graft-versus-host disease using HLA-A, -B and -DR identical unrelated bone marrow donors as with HLA-identical siblings Bone Marrow Transplantation 15(4): 619-625
Oluwole, S.F.; Engelstad, K.; Hardy, M.A. 1992: Kinetics of prevention of graft-versus-host disease and bone marrow rejection by ultraviolet B modulation of bone marrow inoculum Transplantation Proceedings 24(6): 2858-2859
Locatelli, F.; Bongiorno, M.; Zecca, M.; Giani, S.; Giorgiani, G.; Guagnini, R.; Morandi, P.; Porta, F.; Nespoli, L.; Burgio, G.R. 1991: Allogeneic bone marrow transplantation in children from other than HLA-identical sibling donor Bone Marrow Transplantation 7(Suppl 3): 124-127
Iwabuchi, K. 1986: A study of proliferative responses to host Ia antigens in fully allogeneic bone marrow chimeras in mice--sequential analysis of the reactivity and characterization of the cells involved in the response Hokkaido Journal of Medical Science 61(6): 869-882
Jiang, Y.Z.; Kanfer, E.J.; Macdonald, D.; Cullis, J.O.; Goldman, J.M.; Barrett, A.J. 1991: Graft-versus-leukaemia following allogeneic bone marrow transplantation: emergence of cytotoxic T lymphocytes reacting to host leukaemia cells Bone Marrow Transplantation 8(4): 253-258
Shinohara, K.; Tanaka, M.; Matsuda, M.; Tanaka, H.; Fujii, Y.; Yamada, K.; Kaneko, T. 1990: Gamma interferon production and two-color fluorescence flow cytometry analysis of peripheral blood mononuclear cells in allogeneic bone marrow transplant recipients Nihon Ketsueki Gakkai Zasshi: Journal of Japan Haematological Society 53(1): 76-83
Lum, L.G.; Joshi, I.D.; Smith, M.R.; Ratanatharathorn, V.; Galoforo, S.C.; Karanes, C.; Uberti, J.P.; Sensenbrenner, L.L. 1994: Constitutive and mitogen-stimulated cytokine mRNA expression by peripheral blood mononuclear cells from most autologous and allogeneic bone marrow transplant recipients is intact Bone Marrow Transplantation 13(2): 187-195
Cooley, M.A. 1987: Cytokine activity after human bone marrow transplantation. Production of interferons by peripheral blood mononuclear cells from recipients of HLA-identical sibling bone marrow transplants Journal of Immunology 138(11): 3742-3745
Cesbron, A.; Moreau, P.; Milpied, N.; Muller, J.Y.; Harousseau, J.L.; Bignon, J.D. 1990: Influence of HLA-DP mismatches on primary MLR responses in unrelated HLA-A, B, DR, DQ, Dw identical pairs in allogeneic bone marrow transplantation Bone Marrow Transplantation 6(5): 337-340
Johnsen, H.E. 1993: Predictors of acute graft-versus-host disease in bone marrow transplantation between HLA-identical siblings New England Journal of Medicine 328(20): 1497-1498
del Rosario Uriarte, M.; Bonomi, R.; Azambuja, C.; Seuánez, H.N. 1997: Bone marrow reconstitution with normal autologous cells demonstrated by VNTR analysis after allogeneic bone marrow transplantation for chronic myelogenous leukemia Leukemia 11(12): 2213-2214
Mehta, J.; Powles, R.; Horton, C.; Milan, S.; Singhal, S.; Treleaven, J. 1995: Relationship between donor-recipient blood group incompatibility and serum bilirubin after allogeneic bone marrow transplantation from HLA-identical siblings Bone Marrow Transplantation 15(6): 853-858
Marmont, A. 1978: Macrophages in bone marrow transplant rejection Haematologica 63(1): 91-93
de Witte, T.; Janssen, J.; de Pauw, B.; Holdrinet, R.; Wessels, J.; Haanen, C. 1986: Prevention of graft-vs-host disease following allogeneic bone marrow transplantation Nederlands Tijdschrift Voor Geneeskunde 130(28): 1290-1291