Effect of medroxyprogesterone acetate (MAP) and vitamin C on DMBA induced rat mammary cancer in relation to estrogen receptor (ER)
Iino, Y.; Yamazaki, K.; Ogawa, T.; Hirai, T.; Arai, T.; Ishikawa, H.; Endo, K.; Kawai, T.; Izuo, M.; Takikawa, H.
Gan no Rinsho. Japan Journal of Cancer Clinics 29(9): 949-954
1983
ISSN/ISBN: 0021-4949 PMID: 6225884 Document Number: 216577
In mature male and female SD rats, the anti-weight gain effect of durabolin plus vitamin C or vitamin C alone was statistically significant compared to durabolin-treated and control rats. The anti-tumor and anti-weight gain effects of MAP plus vitamin C on DMBA-induced rat mammary cancer were compared with those of MAP and vitamin C in relation to ER. An anti-tumor effect was noted in the MAP treated groups, irrespective of the ER status; it was more pronounced in the MAP (100 mg/kg) plus vitamin C treated group with ER+tumors. Among the ER+tumor groups, weight gain was remarkable in the MAP-treated (20 mg/kg) animals; an anti-weight gain effect was seen in the MAP (20 mg/kg) plus vitamin C group.