Effect of nicotinamide on generalized convulsions in mice
Kryzhanovskiĭ, G.N.; Shandra, A.A.; Godlevskiĭ, L.S.
Farmakologiia i Toksikologiia 45(6): 13-17
1982
ISSN/ISBN: 0014-8318 PMID: 6217985 Document Number: 185033
It was shown in acute experiments on mice that nicotinamide in doses of 250-500 mg/kg given intraperitoneally increased the latent period of corasole clonico-tonic convulsions without affecting their expressiveness and mortality. When given in a dose of 1000 mg/kg nicotinamide prevented clonico-tonic convulsions and mortality, and considerably raised the latent period of convulsions and the lifespan of the animals intoxicated with thiosemicarbazide and strychnine. The expressiveness of the nicotinamide effects depended on the time of its administration.