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Fatal hepatitis during sulfasalazine treatment

Larcan, A.; Lambert, H.; Janot, C.; Perarnaud, J.; Delorme, N.; Tonnel, F.

Therapie 37(3): 315-319

1982

ISSN/ISBN: 0040-5957
PMID: 6127817
Document Number: 183833
Fatal hepatitis was seen with cytolysis, encephalopathy and hepatocellular failure in the course of a treatment with sulfasalazine (2 g/day for 3 wk) for Crohn's disease. The drug's responsibility seemed to be quite probable (hypereosinophilia, positive test of lymphoblastic transformation, positive investigation of circulating immune complexes). The histopathology was that of a necrosing hepatitis with inflammatory modification of porta hepatis. Comparison with 6 observations in the literature suggest an immuno-allergic mechanism.

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