Fatal hepatitis during Epstein-Barr virus reactivation
Cacopardo, B.; Nunnari, G.; Mughini, M.T.; Tosto, S.; Benanti, F.; Nigro, L.
European Review for Medical and Pharmacological Sciences 7(4): 107-109
2003
ISSN/ISBN: 1128-3602 PMID: 15068233 Document Number: 562914
Fulminant hepatitis by Epstein-Barr virus is a rare event which is predominantly due to primary infection. We report a rare case of fatal hepatic failure due to Epstein-Barr virus reactivation in a 19-year-old boy who was taking oral steroids. Transaminase peak and the fulminant course of the disease began soon after steroid interruption. Epstein-Barr virus reactivation was diagnosed on the basis of past clinical history of heterophile-positive infectious mononucleosis, a high titer of IgG anti Epstein-Barr virocapsidic antigen, slight elevation of anti-virocapsidic IgM, a high titer of anti-EA IgG antibodies and elevated viral load in serum measured by polymerase chain reaction. It is concluded that Epstein-Barr virus should be considered as a possible etiological agent of fulminant hepatitis.