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Relation between neutralization of Epstein-Barr virus and antibodies to cell-membrane antigens-induced by the virus

Pearson, G.; Dewey, F.; Klein, G.; Henle, G.; Henle, W.

Journal of the National Cancer Institute 45(5): 989-995

1970

ISSN/ISBN: 0027-8874
PMID: 18605425
Document Number: 28821
The neutralization of Epstein-Barr virus (EBV) infectivity by sera with known antibody activities against EBV-associated antigens was investigated in experimentally infected Raji and RPMI 64-10 cells. Antibodies against EBV-induced cell-membrane antigens were apparently responsible for neutralization of viral infectivity. Antibodies against EBV capsid antigens and EBV-induced early antigens were not involved. The implication of these results on the relationship of the membrane antigens to the infectious virus particle is discussed.

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