Effect of clofeline and apressin on systemic arterial pressure and the tone of cerebral and peripheral vessels
Sankina, Z.V.; Gaevyĭ, M.D.
Farmakologiia i Toksikologiia 44(2): 181-184
1981
ISSN/ISBN: 0014-8318 PMID: 7274425 Document Number: 181415
Resistography was used to demonstrate in acute experiments on anesthetized cats that intravenous injection of clofelin (2,6 and 10 microgram/kg) and apressin (1, 2.5 and 5 microgram/kg) induced a dose-dependent decline in the arterial blood pressure which was not infrequently preceded by short-lived hypertension. Clofelin induced an increase in the tone of cerebral vessels while apressin reduced it. As regards femoral vessels both the drugs produced diverse (sometimes phasic) reactions, with vasodilation being predominant.