Effect of clofelin and apressin on the autoregulation of cerebral blood flow
Gaevyĭ, M.D.; Sankina, Z.V.; Tkhak, C.K.
Farmakologiia i Toksikologiia 46(6): 32-36
1983
ISSN/ISBN: 0014-8318 PMID: 6653755 Document Number: 211431
Acute experiments on cats under mild sodium ethaminal anesthesia and local novocaine anesthesia were made to determine the autoregulative reactions (AR) of the cerebral vessels to different levels of arterial pressure (AP). After clofelin administration the autoregulation borders shifted to the right i. e. towards higher AP levels. Unlike clofelin, apressin made the AP borders shift to the left, i. e. towards lower AP levels. Possible mechanisms of the effects seen and their importance for medicine are discussed.