Effect of methylapogalanthamine on the tone of cerebral, extracranial and peripheral vessels
Pogorelyĭ, V.E.; Gaevyĭ, M.D.
Biulleten' Eksperimental'noi Biologii i Meditsiny 86(10): 438-441
1978
ISSN/ISBN: 0365-9615 PMID: 708872 Document Number: 138995
In anesthetized and nonanesthetized hypertensive cats methylapogalanthamine decreased the total arterial pressure, the tone of cerebral vessels, extracranial and femoral vessels. The effect on the latter was more pronounced. A 2 phase reaction (dilatation-constriction) was not rare. Methylapogalanthamine diminished the constriction reaction of cranial vessels in response to stimulation of the cervical sympathetic nerves. The vasodilator action of methylapogalanthamine was enhanced by anesthesia and decreased by Rausedil.