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Role of some biogenic amines in the pathomechanism of glomerulonephritis. I. Histological examinations of kidneys in acute and chronic serum sickness in rabbits

Szajner-Milart, I.; Rubaj, B.; Zajaczkowska, M.

Acta Physiologica Polonica 32(4): 349-362

1981

ISSN/ISBN: 0044-6033
PMID: 6460419
Document Number: 180177
Investigations were carried out on the role of biogenic amines in the development of glomerulonephritis in rabbits using the experimental model of acute and chronic serum sickness. The animals immunized with foreign for reducing the level of biogenic amines. The results of histological examinations demonstrated a clear cut inhibitory effect of PCPA and reserpine on the development of inflammatory changes in the glomeruli, and their intensification with simultaneous 5HT administration. Apparently, biogenic amines play a significant role in the pathogenesis of inflammatory lesions developing in renal glomeruli in acute or chronic serum sickness in rabbits.

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