Cortical infarction in rabbits with serum sickness following Cyclosporin a therapy
Neild, G.H.; Ivory, K.; Williams, D.G.
Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association 20: 662-668
1983
ISSN/ISBN: 0071-2736 PMID: 6657686 Document Number: 199029
Rabbits given acute serum sickness (ASS) and treated with Cyclosporin A (CyA) developed glomerular capillary thrombosis and cortical infarction. These lesions were associated with severe endothelial injury and platelet-fibrin-leucocyte thrombi. They were not seen in untreated rabbits with ASS, nor in normal rabbits given CyA alone in equivalent doses. A similar renal lesion has been reported in patients receiving CyA following bone marrow transplantation.