In vitro studies on antacids/Third communication
Schnekenburger, J.
Arzneimittel-Forschung 31(8): 1286-1290
1981
ISSN/ISBN: 0004-4172 PMID: 6271146 Document Number: 179435
With an automated method, four antacid gel formulations were tested for antacid in vitro activity. In addition, some elements involved in the buffer effect were assayed in the solution parallel to the in vitro test. Of the four formulations, one showed only insufficient buffer effect. Compared with the common proton/metal ion exchange of antacid buffering, experimental data of another formulation suggest a partially different proton binding mechanism.
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