The bioavailability of trapidil from suppositories
Bornschein, M.; Grohmann, A.; Hackenberger, F.; Grune, D.
Die Pharmazie 36(12): 830-832
1981
ISSN/ISBN: 0031-7144 PMID: 7330086 Document Number: 179434
In a study with five healthy persons designed to compare the bioavailability of Trapidil from Rosupol U suppositories with that from Witepsol H 15 suppositories, the availability of Trapidil from the Rosupol U suppositories was inferior in four of the five test subjects. The difference in the amounts of released drug observed in vivo was smaller than that found in vitro.
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